Key result
Higher baseline serum uric acid linked to slower cognitive decline in adults without hyperuricemia.
Why the study?
The association between serum uric acid and cognitive function remains unclear, especially among individuals without hyperuricemia.
Is serum uric acid associated with cognitive function and decline in middle-aged and older adults without hyperuricemia?
Population
6,236 Chinese adults without hyperuricemia, aged 58.3 ± 8.5 years
Comparison
Higher versus lower baseline serum uric acid levels
Design
Cohort study using bivariate latent change score models and mediation analysis
Follow-up
From Wave 1 to Wave 3
Authors
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Higher uric acid may link to slower cognitive decline in non-hyperuricemic adults; hypothesis-generating and should not yet change practice.
Cohort (n=6,236)
Yes
Is serum uric acid associated with cognitive function and decline in middle-aged and older adults without hyperuricemia?
Effect estimate: standardized β = 0.026
p-value: p=0.027
Higher baseline serum uric acid levels are associated with better baseline cognition and slower cognitive decline in adults without hyperuricemia, partially mediated by depressive symptoms.
Zhang et al. (2023) conducted a cohort in Cognitive decline in adults without hyperuricemia (n=6,236). Serum uric acid vs. Lower serum uric acid levels was evaluated on Subsequent cognitive decline (standardized β = 0.026, p=0.027). Higher baseline serum uric acid was associated with slower subsequent cognitive decline (standardized β = 0.026; p = 0.027) among Chinese adults without hyperuricemia.