Key result
Cell membranes primarily regulate calcium entry and extrusion during excitation-contraction coupling in arterial smooth-muscle cells.
Why the study?
The mechanisms of excitation-contraction coupling in arterial smooth-muscle cells, including membrane potential, force development, and calcium exchange, were not fully understood.
In vitro Ca-handling mechanisms in arterial smooth muscle leave open in vivo relevance; hypothesis-generating for vascular research.
In this study of the excitation-contraction coupling in arterial smooth-muscle cells, the relations between changes of the membrane potential, force development, and 45Ca exchange have been investigated. It is proposed that the cell membrane plays a primary role by regulating the Ca entry into smooth-muscle cells and by extruding the excess cytoplasmic Ca. The possible relation between the receptor-operated channels and the sarcoplasmic reticulum has been discussed, and the peculiar differences between exogenous noradrenaline and noradrenaline released from the nerve terminals have been described.
No takes yet. Share an insight, caveat, or question.
Casteels et al. (1984) studied Arterial smooth-muscle cell physiology. The cell membrane plays a primary role in regulating calcium entry and extruding excess cytoplasmic calcium during excitation-contraction coupling in arterial smooth-muscle cells.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: