Key result
Fasting >2 hours beyond preoperative guidelines is linked to higher ketones and anion gap in children.
Why the study?
Actual preoperative fasting times in paediatric anaesthesia are often longer than guidelines recommend, potentially affecting metabolic parameters in young children.
Does prolonged preoperative fasting affect glucose concentration, ketone bodies, and acid-base balance in children younger than 36 months?
Observational (n=100)
No
Does prolonged preoperative fasting affect glucose concentration, ketone bodies, and acid-base balance in children younger than 36 months?
p-value: p=<0.05
Prolonged preoperative fasting in children under 36 months is associated with ketoacidosis despite normal blood glucose concentrations, highlighting the need to adhere to fasting guidelines.
No takes yet. Share an insight, caveat, or question.
May support minimizing fasting deviations in young children; hypothesis-generating for outcome trials.
Dennhardt et al. (2015) conducted an observational in elective paediatric surgery (n=100). Prolonged preoperative fasting vs. Fasting times with deviation from guidelines <2 hours was evaluated on glucose concentration, ketone bodies and acid-base balance (p=<0.05). Prolonged preoperative fasting deviating from guidelines by >2 hours in children under 36 months was significantly associated with higher ketone bodies, osmolality, and anion gap (P<0.05).
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