Key result
Trial protocol evaluates transcatheter ASD closure followed by bosentan and sildenafil for pulmonary hypertension.
Why the study?
A treatment strategy for patients with pulmonary hypertension and atrial septal defect remains unclear.
Does transcatheter ASD closure followed by bosentan and sildenafil improve pulmonary artery pressure and pulmonary vascular resistance in patients with pulmonary hypertension associated with atrial septal defect?
Does transcatheter ASD closure followed by bosentan and sildenafil improve pulmonary artery pressure and pulmonary vascular resistance in patients with pulmonary hypertension associated with atrial septal defect?
This study protocol outlines an interventional trial to evaluate the feasibility and hemodynamic effects of a 'repair and treat' strategy (ASD closure followed by bosentan and sildenafil) in patients with ASD-associated pulmonary hypertension.
Answers are grounded in this paper and cite their sources.
Outlines protocol for combined ASD closure and dual PAH therapy; hypothesis-generating for hemodynamic effects in ASD-PH.
A treatment strategy for patients with pulmonary hypertension (PH) and atrial septal defect (ASD) remains unclear. This study was designed to evaluate the effects of initial repair of ASD followed by treatment with PH-specific drugs in patients with PH and ASD. Eligible patients receive transcatheter ASD closure followed by treatment with bosentan and sildenafil. Right heart catheterization is performed at baseline and at 12, 24 and 48 weeks. The primary endpoint is change in pulmonary artery pressure and pulmonary vascular resistance from baseline to follow-up. This study should provide valuable information to establish a therapeutic strategy for PH and ASD.
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Akagi et al. (2016) studied Pulmonary hypertension associated with atrial septal defect. Transcatheter ASD closure followed by bosentan and sildenafil was evaluated on Change in pulmonary artery pressure and pulmonary vascular resistance from baseline to follow-up. This study protocol describes an interventional trial to evaluate transcatheter ASD closure followed by bosentan and sildenafil in patients with pulmonary hypertension and atrial septal defect.
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