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September 19, 2026Phytochemistry ReviewsOpen Access

Evidence-based evaluation of berberine in neurodegenerative diseases: targeting multiple signaling pathways and modulating neuroinflammation, oxidative stress, and apoptosis

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Authors

MRMd. Saidur RahamanARAbdur RaufMIMd. Rezaul Islam

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Rahaman et al. (2026) studied this question.

synapsesocial.com/papers/6ab097f8f1d612af1803bf04https://doi.org/10.1007/s11101-026-10321-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gold nanoclusters conjugated berberine reduce inflammation and alleviate neuronal apoptosis by mediating M2 polarization for spinal cord injury repair2021 · 37 citations
  2. 2An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases2022 · 1,075 citations
  3. 3Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease2021 · 58 citations
  4. 4Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine2018 · 40 citations
  5. 5Protective effects of berberine against MPTP-induced dopaminergic neuron injury through promoting autophagy in mice2021 · 39 citations