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An islet cell tumor of the pancreas with unusual light microscopic, ultrastructural, and immunocytochemical features is reported. In addition to secretory granules and positive immunostaining for pancreatic polypeptide, the tumor contained globoid intracytoplasmic inclusions by light and electron microscopy, which correlated with a positive immunoreaction for alpha-1-antitrypsin, and Reinke-like crystals.
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Ordóǹez et al. (1985) studied this question.
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