Key result
A proposed sympathoexcitatory pathway links medullary depressor and pressor areas to control brain vessels.
Why the study?
The different roles of pathways from the CVL to the RVL in controlling cerebral versus systemic vessels and their contribution to regional sympathetic nerve activity differences were unclear.
Key points are not available for this paper at this time.
Comparison
Sympathoexcitatory pathway vs sympathoinhibitory pathway from CVL to RVL
Design
Experimental study investigating neural pathways controlling brain vessels
We reported a regional differentiation of blood flow responses during the activation of the nucleus tractus solitarius (NTS) and caudal ventrolateral medullary depressor area (CVL). The neurons in the NTS and CVL have a vasoconstrictor effect on brain circulation and a vasodilator effect on systemic circulation. On the other hand, the neurons in the rostral ventrolateral medullary pressor area (RVL) have a vasoconstrictor effect on both brain and systemic circulation. We therefore hypothesized that there is a sympathoexcitatory pathway from the CVL to the RVL for controlling cerebral vessels and a sympathoinhibitory pathway from the CVL to the RVL for controlling systemic vessels, and that these different roles of the pathways from the CVL to the RVL for the different organs can explain the regional difference in sympathetic nerve activities. Here, we propose a sympathoexcitatory pathway from the CVL to the RVL for controlling brain vessels.
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Maeda et al. (2008) studied this question. A sympathoexcitatory pathway from the caudal ventrolateral medullary depressor area to the rostral ventrolateral medullary pressor area is proposed for controlling brain vessels.
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