February 1, 2001AJP Regulatory Integrative and Comparative PhysiologyOpen Access

Glutamatergic and GABAergic inputs to the RVL mediate cardiovascular adjustments to noxious stimulation

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Population

Urethane-anesthetized, paralyzed, and artificially ventilated rats

Design

Preclinical

Authors

OPOlga S. PossasUniversity of Iowa OLOswaldo Ubrı́aco LopesUniversidade Federal de São Paulo SCSérgio L. CravoUniversidade Federal de São Paulo

Discussion

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Implication

Identifies distinct RVL glutamatergic and GABAergic mediation of SNS responses in rats; leaves open translation to human cardiovascular control.

Structured PICO

Population

Urethane-anesthetized, paralyzed, and artificially ventilated rats

Intervention

Unilateral microinjection of kainic acid (2 nmol/100 nl), kynurenic acid (2 nmol/100 nl), or bicuculline (400 pmol/100 nl) into the rostral ventrolateral medulla (RVL) combined with sciatic nerve stimulation (SNS)

Outcome

Cardiovascular adjustments to SNS (blood pressure, heart rate, blood flow, and vascular conductance of the stimulated limb)surrogate

In a rat model, glutamatergic synapses within the RVL mediate pressor responses to noxious stimulation, while GABAergic synapses mediate vasodilation.

Cite This Study

Possas et al. (2001) studied this question.

synapsesocial.com/papers/6a7d39e70ae9e6500d83dbf9 https://doi.org/10.1152/ajpregu.2001.280.2.r434

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Implication

Identifies distinct RVL glutamatergic and GABAergic mediation of SNS responses in rats; leaves open translation to human cardiovascular control.

Glutamatergic and GABAergic inputs to the RVL mediate cardiovascular adjustments to noxious stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Glutamatergic and GABAergic inputs to the RVL mediate cardiovascular adjustments to noxious stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider