January 1, 2007Clinical and Experimental Hypertension

Cardiovascular Responses to Somatosensory Stimulation and Their Modulation by Baroreflex Mechanisms

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Population

Urethane-anesthetized, artificially ventilated, adult male Wistar rats

Comparison

Sciatic nerve stimulation with various modulations vs Unmodulated responses to sciatic nerve stimulation

Design

Preclinical

Authors

TKTetsuya KawabeWakayama Medical University KKKazumi KawabeHidaka Hospital HSHreday N. SapruRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Rat brainstem mechanisms are hypothesis-generating; leaves open translation to human somatosensory cardiovascular control.

Structured PICO

Population

Urethane-anesthetized, artificially ventilated, adult male Wistar rats

Intervention

Sciatic nerve stimulation with various modulations (muscimol inhibition of RVLM, muscimol inhibition of mNTS, microinjections of ionotropic glutamate receptor antagonists into mNTS, barodenervation, unilateral stimulation of aortic nerve)

Comparator

Unmodulated responses to sciatic nerve stimulation

Outcome

Cardiovascular responses (pressor and tachycardic responses)surrogate

In a rat model, ascending afferents in the sciatic nerve project bilaterally to the RVLM and mNTS, with baroreflex mechanisms modulating the cardiovascular responses to somatosensory stimulation.

Cite This Study

Kawabe et al. (2007) studied this question.

synapsesocial.com/papers/6a7d39e70ae9e6500d83dbf2 https://doi.org/10.1080/10641960701578402

View Full Paper

Ask AI

Bookmark

Cardiovascular Responses to Somatosensory Stimulation and Their Modulation by Baroreflex Mechanisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiovascular Responses to Somatosensory Stimulation and Their Modulation by Baroreflex Mechanisms

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider