What question did this study set out to answer?

To identify the central neural pathways and brainstem nuclei responsible for mediating the somatic pressor reflex elicited by peripheral sensory nerve stimulation.

February 1, 1989AJP Regulatory Integrative and Comparative Physiology

Neurons of rostral ventrolateral medulla mediate somatic pressor reflex

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Authors

RSRuth L. StornettaWest Virginia University SMS. F. MorrisonUniversity of Vermont DRDavid A. RuggieroState University of New York

Discussion

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Implication

In vivo animal study reveals that rostral ventrolateral medulla neurons mediate the somatic pressor reflex in rats, demonstrating a critical brainstem pathway for blood pressure regulation.

Key Points

To identify the central neural pathways and brainstem nuclei responsible for mediating the somatic pressor reflex elicited by peripheral sensory nerve stimulation.
Electrically stimulated cutaneous (sciatic, sural) and muscle (femoral, tibial) afferents in anesthetized, paralyzed rats while measuring arterial blood pressure responses.
Performed midpontine transections, unilateral spinal hemisections, and targeted chemical (kainic acid) or electrolytic lesions across candidate autonomic brainstem sites, including the rostral ventrolateral medulla (RVL).
Mapped neuronal connections using horseradish peroxidase retrograde axonal transport to examine projections from dorsal horn spinoreticular neurons to the RVL.
Stimulation of cutaneous afferents raised arterial pressure by 5 to 40 mmHg, while muscle afferent stimulation produced a depressor response.
The pressor reflex was selectively abolished by contralateral lumbar hemisection and contralateral lesions of the RVL overlapping C1 adrenergic neurons, but remained intact following midpontine transection or lesions of the lateral reticular nucleus, A5 area, parabrachial nucleus, or nucleus tractus solitarii.
Sciatic nerve afferent terminals directly overlapped dorsal horn spinoreticular neurons that retrogradely labeled from tracer injections in the contralateral RVL.

Cite This Study

Stornetta et al. (1989) studied this question.

synapsesocial.com/papers/6a70fda83ce530166bc2fba4 https://doi.org/10.1152/ajpregu.1989.256.2.r448

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Implication

In vivo animal study reveals that rostral ventrolateral medulla neurons mediate the somatic pressor reflex in rats, demonstrating a critical brainstem pathway for blood pressure regulation.

Neurons of rostral ventrolateral medulla mediate somatic pressor reflex

Discussion

Member takes

Implication

Key Points

Cite This Study

Neurons of rostral ventrolateral medulla mediate somatic pressor reflex

Discussion

Member takes

Implication

Key Points

Cite This Study

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