Why the study?
Does blockade of EAA receptors in the RVLM reduce MAP, HR, and RSNA after inhibition of CVLM neurons in anesthetized rats?
Population
Anesthetized rats
Comparison
Bilateral injections of kynurenic acid in the… vs Vehicle injection alone in the RVLM after…
Design
Preclinical
Follow-up
approximately 50 min
Authors
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Suggests minimal EAA contribution to RVLM tonic drive in rats; leaves open non-EAA or intrinsic mechanisms for presympathetic neuron activity.
Does blockade of EAA receptors in the RVLM reduce MAP, HR, and RSNA after inhibition of CVLM neurons in anesthetized rats?
Removal of tonic excitatory amino acid drive to RVLM neurons has little effect on the tonic activity of RVLM presympathetic neurons, suggesting dependence on non-EAA receptors or autoactivity.
Horiuchi et al. (2004) studied this question.
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