Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 25, 2008HypertensionOpen Access

Tonic Glutamatergic Input in the Rostral Ventrolateral Medulla Is Increased in Rats With Chronic Heart Failure

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do glutamate receptor antagonists in the RVLM reduce sympathetic tone in rats with chronic heart failure?

Population

Rats with chronic heart failure (CHF) produced by coronary artery ligation, and sham rats.

Comparison

Bilateral microinjection of glutamate receptor… vs Sham rats receiving the same injections.

Design

Preclinical

Authors

WWWei-Zhong WangLGLie GaoHWHan-Jun Wang

Discussion

Loading...

Member takes

Overview

Implicates upregulated RVLM glutamate receptors in rat CHF sympathetic overdrive; hypothesis-generating for human translation.

Structured PICO

Do glutamate receptor antagonists in the RVLM reduce sympathetic tone in rats with chronic heart failure?

P
Population
Rats with chronic heart failure (CHF) produced by coronary artery ligation, and sham rats.
I
Intervention
Bilateral microinjection of glutamate receptor antagonists (kynurenic acid, D-2-amino-5-phosphonopentanoate, or 6-cyano-7-nitroquinoxaline-2,3-dione) into the rostral ventrolateral medulla (RVLM).
C
Comparator
Sham rats receiving the same injections.
O
Outcome
Resting blood pressure, renal sympathetic nerve activity, and basal discharge of RVLM presympathetic neurons.surrogate

Upregulated glutamate receptors in the RVLM are involved in the tonic control of elevated sympathetic tone in chronic heart failure.

Cite This Study

Wang et al. (2008) studied this question.

synapsesocial.com/papers/6a1e860940bc8a3dd76903d3https://doi.org/10.1161/hypertensionaha.108.122598
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alteration of NMDA NR <sub>1</sub> Receptors Within the Paraventricular Nucleus of Hypothalamus in Rats With Heart Failure2003 · 124 citations
  2. 2The Regulation of Sympathetic Outflow in Heart Failure2001 · 92 citations
  3. 3Blockade of angiotensin AT1-receptors in the rostral ventrolateral medulla of spontaneously hypertensive rats reduces blood pressure and sympathetic nerve discharge2001 · 54 citations
  4. 4Paraventricular nucleus of the hypothalamus and elevated sympathetic activity in heart failure: the altered inhibitory mechanisms2002 · 142 citations
  5. 5Role Of Angiotensin II Receptors In The Regulation Of Vasomotor Neurons In The Ventrolateral Medulla2002 · 98 citations