Key result
Higher skin autofluorescence and plasma pentosidine are linked to increased cfPWV and central pulse pressure.
Why the study?
Advanced glycation end products are hypothesized to play a role in the development of arterial stiffness, especially in individuals with type 2 diabetes mellitus.
Are skin autofluorescence and plasma pentosidine associated with arterial stiffening in individuals with varying degrees of glucose metabolism?
Cross-Sectional (n=862)
Are skin autofluorescence and plasma pentosidine associated with arterial stiffening in individuals with varying degrees of glucose metabolism?
Effect estimate: sβ 0.10 (95% CI 0.03-0.17)
Accumulation of advanced glycation end products, estimated by skin autofluorescence and plasma pentosidine, is independently associated with arterial stiffening, particularly in patients with type 2 diabetes.
AGE markers associated with stiffening across glucose metabolism; hypothesis-generating and requires prospective trials before clinical adoption.
Arterial stiffening, as characterized by an increase in carotid-femoral pulse-wave velocity or pulse pressure, increases the risk of cardiovascular disease, especially among individuals with type 2 diabetes mellitus. Advanced glycation end products are hypothesized to play a role in the development of arterial stiffness. Therefore, we investigated the association between skin autofluorescence, an estimate of tissue advanced glycation end products, and plasma advanced glycation end products on the one hand and arterial stiffening on the other in 862 participants of The Maastricht Study (mean age of 60 years; 45% women) with normal glucose metabolism (n=469), impaired glucose metabolism (n=140), or type 2 diabetes (n=253). Associations were analyzed with linear regression analysis and adjusted for potential confounders. We found that higher skin autofluorescence as measured by the AGE Reader and plasma pentosidine were independently associated with higher carotid-femoral pulse-wave velocity (sβ 0.10; 95% confidence interval, 0.03-0.17 and 0.10; 0.04-0.16, respectively) and central pulse pressure (sβ 0.08; 95% confidence interval 0.01-0.15 and 0.07; 0.01-0.13, respectively). The associations between skin autofluorescence and pentosidine, and carotid-femoral pulse-wave velocity were more pronounced in individuals with type 2 diabetes mellitus (P-interaction<0.10). These results support the hypothesis that accumulation of advanced glycation end products is involved in arterial stiffening and may explain part of the increased risk of cardiovascular disease in individuals with type 2 diabetes mellitus.
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Eupen et al. (2016) conducted a cross-sectional in Normal glucose metabolism, impaired glucose metabolism, or type 2 diabetes (n=862). Skin autofluorescence and plasma pentosidine was evaluated on carotid-femoral pulse-wave velocity (sβ 0.10, 95% CI 0.03-0.17). Higher skin autofluorescence and plasma pentosidine were independently associated with higher carotid-femoral pulse-wave velocity (sβ 0.10; 95% CI 0.03-0.17) and central pulse pressure.
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