Key result
Lidoflazine plus physical training lowers submaximal heart rate vs placebo with similar symptom-limited exercise capacity.
Why the study?
An additive effect of combining lidoflazine and physical training in the treatment of stable angina pectoris was postulated but not established.
Does lidoflazine combined with physical training improve exercise tolerance and physiological parameters in patients with stable angina pectoris?
RCT (n=24)
randomly divided
Does lidoflazine combined with physical training improve exercise tolerance and physiological parameters in patients with stable angina pectoris?
Lidoflazine added to physical training significantly reduces submaximal heart rate but does not provide additive benefits to exercise capacity compared to physical training alone in stable angina.
Answers are grounded in this paper and cite their sources.
Adding lidoflazine to training yields no extra exercise capacity gain in stable angina; challenges combined-therapy rationale despite greater submaximal heart rate reduction.
An additive effect in the treatment of angina pectoris by combining lidoflazine and physical training was postulated. Twenty-four patients were randomly divided into placebo and drug groups and subsequently underwent a 6-month physical training program. The drug group had a significantly greater reduction in submaximal heart rate than the placebo group. Similar improvements in symptom-limited exercise capacity were observed in both groups. Resting and maximal exercise coronary sinus blood flow and left ventricular oxygen consumption were not significantly changed with training in either group. Physical training and lidoflazine appear to influence exercise tolerance in the same manner.
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Ferguson et al. (1979) conducted an RCT in stable angina pectoris (n=24). Lidoflazine vs. Placebo was evaluated on submaximal heart rate. Lidoflazine combined with physical training significantly reduced submaximal heart rate compared to placebo, though both groups showed similar improvements in symptom-limited exercise capacity.
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