Adverse local reactions from accidental BCG overdose in infants

Uncertainty persists about the frequency of adverse neurological and psychiatric events associated with the antimalarial drugs mefloquine and proguanil plus chloroquine * This study shows that about 40% of travellers taking either mefloquine or chloroquine and proguanil can expect to experience some sort of adverse side effect, although most side effects will be relatively trivial * About 0.7% (1 in 140) travellers taking mefloquine can expect to have a neuropsychiatric adverse event unpleasant enough to temporarily prevent them from carrying out their day to day activities, compared with 0.09% (1 in 1100) taking chloroquine and proguanil * *Mefloquine is appropriate only when the risk is high both of malaria and of