Key result
Resolving pediatric OSA is linked to improved total cholesterol, but obesity drives overall metabolic dysfunction.
Why the study?
In children, the relationship between metabolic markers and obstructive sleep apnea (OSA) over time and with treatment had not been studied, unlike in adults.
Does treatment and resolution of obstructive sleep apnea improve metabolic markers in children?
Cohort (n=45)
Does treatment and resolution of obstructive sleep apnea improve metabolic markers in children?
p-value: p=0.005
Obesity is the primary driver of metabolic dysfunction in children with OSA, though resolution of OSA may modestly improve metabolic markers such as total cholesterol over time.
Obesity primarily drives metabolic dysfunction in children with OSA; leaves open whether OSA resolution modestly alters markers over time.
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Waters et al. (2006) conducted a cohort in Obstructive sleep apnea (n=45). Resolution of obstructive sleep apnea vs. Persisting obstructive sleep apnea was evaluated on Change in total cholesterol (p=0.005). Resolution of obstructive sleep apnea in children was associated with a significant improvement in total cholesterol (p=0.005), though obesity was the major influence on metabolic dysfunction.
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