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February 28, 2025MedicineOpen Access

Identification of ferroptosis-related genes in heart tissues of patients with hypertrophic cardiomyopathy

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Key result

Genomic analysis identifies 8 ferroptosis-regulating hub genes linked to immune infiltration in HCM.

Why the study?

The role of ferroptosis and its associated differentially expressed genes in hypertrophic cardiomyopathy was not well understood.

Design

Comprehensive genomic analysis of heart tissues in HCM

Authors

FHFang HuangHebei Medical UniversitySLShujuan LiSouth China Agricultural UniversitySZShaoqiang ZhangTianjin University of Traditional Chinese Medicine

Discussion

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Implication

Hypothesis-generating for ferroptosis genes in HCM; leaves open any clinical role pending validation studies.

Study Design

Type

Observational

PICO

P
Population
Hypertrophic cardiomyopathy
E
Exposure / Comparator
Ferroptosis-related genes
O
Primary Outcome
Differentially expressed genes associated with ferroptosis

Cite This Study

Huang et al. (2025) conducted an observational in Hypertrophic cardiomyopathy. Ferroptosis-related genes was evaluated on Differentially expressed genes associated with ferroptosis. Genomic analysis identified TFRC, SCD, SLC2A1, EGR1, GDF15, SNCA, PLIN2, and NQO1 as hub genes regulating ferroptosis and associated with immune infiltration in hypertrophic cardiomyopathy.

synapsesocial.com/papers/6ab09e424d859910d114f1b5https://doi.org/10.1097/md.0000000000041525

Topics

Hypertrophic cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systemic Bioinformatic Analyses of Nuclear-Encoded Mitochondrial Genes in Hypertrophic Cardiomyopathy2021 · 8 citations
  2. 2Ferroptosis in health and disease2024 · 335 citations
  3. 3Genetic Mutations and Mitochondrial Redox Signaling as Modulating Factors in Hypertrophic Cardiomyopathy: A Scoping Review2024 · 15 citations
  4. 4Critical Evaluation of Current Hypotheses for the Pathogenesis of Hypertrophic Cardiomyopathy2022 · 23 citations
  5. 5Association of Multiple Nonhypertrophic Cardiomyopathy–Related Genetic Variants and Outcomes in Patients With Hypertrophic Cardiomyopathy2024 · 10 citations