Osteonecrosis is recognized increasingly as a complication of the treatment of cancer in young people, especially those with acute lymphoblastic leukemia and non-Hodgkin lymphoma, reflecting a probable pathogenetic role of steroid therapy. Children >/=10 years of age and Whites are at particular risk, and genetic predispositions have been identified. The disorder affects weight-bearing joints predominantly. It is commonly bilateral and multi-articular. Treatment options include both surgical and non-surgical interventions.
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Barr et al. (2007) studied this question.
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