Key result
Vascular EDS is linked to severe maternal complications despite otherwise favorable pregnancy outcomes in EDS.
Why the study?
Pregnant patients with Ehlers-Danlos syndrome have variable risks of maternal complications depending on subtype, necessitating tailored obstetric management guidance.
Early diagnosis and subtype characterization of EDS in pregnancy are crucial for risk assessment and optimal obstetric and anesthetic management, particularly for the high-risk vascular subtype.
Supports caution with vascular EDS in pregnancy; leaves open prospective validation of management strategies.
Ehlers-Danlos syndrome (EDS) is a group of connective tissue disorders that can result in a range of complications during pregnancy. Pregnant EDS patients generally have a favourable outcome, but those with vascular EDS are more likely to suffer from severe maternal complications. Early diagnosis of EDS and subtype characterization can aid in pre-pregnancy counselling, planning of antenatal care, risk assessment of obstetric and neonatal complications, and influence both obstetric and anaesthetic management of these patients. This piece aims to outline the obstetric implications of classical, hypermobile, and vascular EDS, and review the current literature regarding their optimal obstetric management.
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Kang et al. (2020) conducted a review in Ehlers-Danlos syndrome in pregnancy. Ehlers-Danlos syndrome was evaluated. Pregnant patients with Ehlers-Danlos syndrome generally have a favorable outcome, but those with vascular EDS are more likely to suffer from severe maternal complications.
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