Key result
Dabigatran shows no significant benefit over warfarin for bleeding in patients with liver cirrhosis.
Why the study?
The safety of dabigatran in patients with liver cirrhosis and its bleeding risk compared to warfarin is poorly studied.
Does dabigatran reduce the incidence of bleeding events resulting in hospital admission compared to warfarin in adults with liver cirrhosis?
Cohort (n=100)
Yes
Does dabigatran reduce the incidence of bleeding events resulting in hospital admission compared to warfarin in adults with liver cirrhosis?
Answers are grounded in this paper and cite their sources.
In patients with liver cirrhosis, dabigatran showed a numerically lower but not statistically significant risk of bleeding requiring hospitalization compared to warfarin.
AIM: The safety of dabigatran is poorly studied in patients with liver cirrhosis and has rarely been compared to warfarin in terms of bleeding risks. METHOD: We undertook a retrospective cohort study across three tertiary centres in Auckland, New Zealand, between 2008 to 2020. Adults 18 years and over and those with a clinically confirmed diagnosis of cirrhosis were included. Data collected included demographic data and clinical characteristics, baseline medication and comorbidities. The primary outcome measure was the incidence of any bleeding event that resulted in hospital admission. RESULTS: Overall, 100 patients were included in this study. A total of 52 patients took warfarin, and 48 took dabigatran. Baseline characteristics for both groups were generally similar. The incidence rate of bleeds for patients taking warfarin was 14.4 per 100 person-years (95% CI, 8.8-23.5) compared to 9.1 per 100 person-years (95% CI, 4.5-18.1) for patients taking dabigatran. The incidence rate ratio comparing dabigatran to warfarin was 0.63 (95% CI, 0.23-1.60), p=0.25. CONCLUSION: Our study found that patients on dabigatran may have a lower bleeding risk than patients taking warfarin, but this was not statistically significant.
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Gong et al. (2022) conducted a cohort in Liver cirrhosis (n=100). Dabigatran vs. Warfarin was evaluated on Incidence of any bleeding event resulting in hospital admission (IRR 0.63, 95% CI 0.23-1.60, p=0.25). Dabigatran was associated with a non-statistically significant lower incidence of bleeding compared to warfarin in patients with liver cirrhosis (IRR 0.63).
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