Key result
Common adenosine A2A receptor variants show no association with altered hemodynamics or ischemia detection post-regadenoson.
Why the study?
Hemodynamic response to regadenoson varies greatly and the underlying mechanisms for this variability are poorly understood.
Do common genetic polymorphisms of the adenosine A2A receptor influence the hemodynamic response or detection of ischemia during regadenoson nuclear stress imaging?
Observational (n=357)
Do common genetic polymorphisms of the adenosine A2A receptor influence the hemodynamic response or detection of ischemia during regadenoson nuclear stress imaging?
Common genetic variants of the adenosine A2A receptor do not explain the clinical variability in hemodynamic response or ischemia detection during regadenoson nuclear stress imaging.
ADORA2A variants were not associated with regadenoson response; leaves open alternative mechanisms of hemodynamic variability.
AIM: Hemodynamic response to regadenoson varies greatly, and underlying mechanisms for variability are poorly understood. We hypothesized that five common variants of adenosine A2A receptor (ADORA2A) are associated with altered response to regadenoson. METHODS: Consecutive subjects (n = 357) undergoing resting regadenoson nuclear stress imaging were enrolled. Genotyping was performed using Taqman-based assays for rs5751862, rs2298383, rs3761422, rs2267076 and rs5751876. RESULTS: There was no significant difference in heart rate or blood pressure between different genotypes following regadenoson administration. There was also no significant difference in myocardial ischemia detected by nuclear perfusion imaging as defined by summed difference score, or in self-reported side effects among the genotypes tested. CONCLUSION: The common A2A variants studied are not associated with variability in hemodynamic response to regadenoson or variability in detection of ischemia with nuclear perfusion stress imaging.
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Berlacher et al. (2017) conducted an observational in Undergoing resting regadenoson nuclear stress imaging (n=357). Adenosine A2A receptor (ADORA2A) genetic variants vs. Different genotypes was evaluated on Heart rate or blood pressure following regadenoson administration. Common genetic variants of the adenosine A2A receptor were not associated with significant differences in hemodynamic response or detection of ischemia following regadenoson administration.
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