Key result
Combining CYP2C19 and CYP2D6 variant data across Oceania is inappropriate due to Melanesian and Polynesian differences.
Why the study?
Pharmacogenetic variants of CYP2C19 and CYP2D6 in Oceania populations have been mainly studied without distinguishing between Melanesian and Polynesian groups, leading to inappropriate combined prevalence data and assumptions.
Pharmacogenetic dosing decisions for drugs like clopidogrel in Pacific peoples should rely on individual assessment rather than broad ethnicity-based assumptions due to significant regional genetic heterogeneity.
Cautions against pooled CYP data for Pacific peoples; leaves open population-specific pharmacogenetic validation.
The study of pharmacogenetic variants in populations which reside in Oceania has been focused mainly on CYP2C19 and CYP2D6. Statements about the high prevalence of CYP2C19 no function genotype in 'Pacific Islanders' can be found in the literature. This review article summarizes the published information about these pharmacogenes in this geographical region and highlights the differences observed between Melanesian and Polynesian populations. It is not appropriate to combine the prevalence data of pharmacogenetic variants, particularly CYP2C19, across this region. Indeed, apocryphal assumptions about CYP2C19 no function alleles and possible effect on the therapeutic activity of clopidogrel are unhelpful and reiterate the importance of assessing the individual patient rather than relying on inappropriate ethnicity-based assumptions for drug dosing decisions.
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Nuala A. Helsby (2016) conducted a review in Pharmacogenetic variants (CYP2C19 and CYP2D6). CYP2C19 and CYP2D6 genotypes was evaluated on Prevalence of pharmacogenetic variants. Combining prevalence data of CYP2C19 and CYP2D6 variants across Oceania is inappropriate due to significant differences between Melanesian and Polynesian populations.
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