What is the clinical evidence from this study?

Study design: Observational. Population: Various diseases without congenital cardiac defects (controls) (n=47). Intervention: Right heart catheterization. Primary outcome: Maximum normal variation in oxygen content between right heart chambers.

What does this research mean for the field?

In control patients without intracardiac shunts, the maximum normal increases in blood oxygen content across right heart chambers are 1.9 vol% from superior vena cava to right auricle, 0.9 vol% from auricle to ventricle, and 0.5 vol% from ventricle to pulmonary artery. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1947Journal of Clinical InvestigationOpen Access

Studies of Congenital Heart Disease. Ii. The Pressure and Oxygen Content of Blood in the Right Auricle, Right Ventricle, and Pulmonary Artery in Control Patients, With Observations on the Oxygen Saturation and Source of Pulmonary “Capillary” Blood 1

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Key result

Right heart catheterization reveals maximum normal oxygen content increases of ~2 vol% between right chambers.

n=47

Population

Control patients

Design

Other

Authors

LDL DexterBoston University FHFlorence W. HaynesUniversity College of the North CBC. Sidney BurwellBrigham and Women's Hospital

Discussion

Member takes

Implication

Early physiological study establishing baseline pressure and oxygen content values in the right heart and pulmonary artery of control patients.

Study Design

Type

Observational (n=47)

Multicenter

Structured PICO

Population

47 patients with various conditions but generally without congenital heart defects undergoing right heart catheterization to establish normal physiological variations in pressure and oxygen content.

Exposure

Measurement of pressure and oxygen content in the right auricle, right ventricle, pulmonary artery, and pulmonary capillary blood

Outcome

Pressure and oxygen content/saturationsurrogate

Early physiological study establishing baseline pressure and oxygen content values in the right heart and pulmonary artery of control patients.

Limitations

Small series of control patients, meaning normal variations encountered could potentially be greater.
Occasional poor mixing of venous blood in the right auricle and right ventricle due to coronary or hepatic venous return.

Cite This Study

Dexter et al. (1947) conducted an observational in Various diseases without congenital cardiac defects (controls) (n=47). Right heart catheterization was evaluated on Maximum normal variation in oxygen content between right heart chambers. Right heart catheterization in control patients revealed maximum normal oxygen content increases of 1.9 vol% (superior vena cava to right auricle), 0.9 vol% (auricle to ventricle), and 0.5 vol% (ventricle to pulmonary artery).

synapsesocial.com/papers/6ab0a4fcc761ef854325dace https://doi.org/10.1172/jci101840

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Implication

Early physiological study establishing baseline pressure and oxygen content values in the right heart and pulmonary artery of control patients.

Studies of Congenital Heart Disease. Ii. The Pressure and Oxygen Content of Blood in the Right Auricle, Right Ventricle, and Pulmonary Artery in Control Patients, With Observations on the Oxygen Saturation and Source of Pulmonary “Capillary” Blood 1

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Studies of Congenital Heart Disease. Ii. The Pressure and Oxygen Content of Blood in the Right Auricle, Right Ventricle, and Pulmonary Artery in Control Patients, With Observations on the Oxygen Saturation and Source of Pulmonary “Capillary” Blood 1

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

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