Studies of the Pulmonary Circulation in Man at Rest. Normal Variations and the Interrelations Between Increased Pulmonary Blood Flow, Elevated Pulmonary Arterial Pressure, and High Pulmonary “Capillary” Pressures 1

42 human subjects studied at rest, including 8 normal patients (some with treated syphilis), 9 with left-to-right shunts (7 atrial septal defect, 2 patent ductus arteriosus), 3 with Eisenmenger's complex, 11 with mitral stenosis, and 11 with left ventricular failure.

Right heart catheterization to measure pulmonary artery pressure, pulmonary 'capillary' (wedge) pressure, cardiac output, and calculate pulmonary arteriolar resistance.

Comparisons made between normal subjects and those with increased pulmonary blood flow (shunts), elevated pulmonary arterial pressure (Eisenmenger's), or high pulmonary capillary pressure (mitral stenosis/LV failure).

Pulmonary hemodynamics including pulmonary artery pressure, pulmonary capillary pressure, pressure gradient, and pulmonary arteriolar resistance.surrogate