What does this research mean for the field?

Pulmonary arterial distensibility accounts for the conduction time of the flow pulse and allows storage of ejected blood during systole to maintain capillary flow continuity, while still transmitting changes in the right ventricular inflow pulse pattern to the capillaries. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the dynamic propagation and characteristics of pulsatile blood flow from the pulmonary valve into the capillary bed in healthy individuals.

July 1, 1969Circulation ResearchOpen Access

Propagation of Blood Flow Pulse in the Normal Human Pulmonary Arterial System: ANALYSIS OF THE PULSATILE CAPILLARY FLOW

View Full Paper

Ask AI

Bookmark

Why the study?

Does administration of atropine, isoproterenol, or exercise alter the propagation of blood flow pulse in the pulmonary arterial system of healthy men?

Population

6 healthy men in the supine position

Design

Other

Authors

NKN. B. KaratzasHygeia Hospital GLGRANT DE J. LEEUniversity of Oxford

Discussion

Member takes

Implication

Quantifies normal pulmonary flow pulse transmission; leaves open whether autonomic agents or exercise alter propagation.

Key Points

To investigate the dynamic propagation and characteristics of pulsatile blood flow from the pulmonary valve into the capillary bed in healthy individuals.
Assessed 6 healthy men in the supine position using the nitrous oxide-body plethysmograph method to track pulmonary capillary blood flow and phonocardiography to time pulmonary valve opening and closure.
Altered right ventricular ejection dynamics by administering atropine and isoproterenol and by applying physical exercise.
Conduction time from the pulmonary valve to capillaries averaged 120 msec, with a systolic capillary acceleration of 8.2 ml/sec/msec and a peak flow rate of 186 ml/sec.
An average of 67.2% of stroke volume distended the pulmonary arterial system during systole, though this storage fraction decreased during tachycardia.
Capillary blood acceleration increased following exercise and isoproterenol administration, while arterial distensibility maintained continuity of capillary blood flow.

Structured PICO

Does administration of atropine, isoproterenol, or exercise alter the propagation of blood flow pulse in the pulmonary arterial system of healthy men?

Population

6 healthy men in the supine position

Intervention

Administration of atropine, isoproterenol, and exercise

Outcome

Pulmonary capillary blood flow pulse characteristics (conduction time, acceleration, fraction of stroke volume distending the arterial system, peak flow rate)surrogate

The pulmonary arterial system acts to store ejected blood during systole and maintain capillary flow continuity, with changes in inflow pulse remaining detectable in the capillary flow pulse despite modifying effects.

Cite This Study

Karatzas et al. (1969) studied this question.

synapsesocial.com/papers/6a1c219bea84844e355f7e5f https://doi.org/10.1161/01.res.25.1.11

View Full Paper

Ask AI

Bookmark

Propagation of Blood Flow Pulse in the Normal Human Pulmonary Arterial System: ANALYSIS OF THE PULSATILE CAPILLARY FLOW

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Propagation of Blood Flow Pulse in the Normal Human Pulmonary Arterial System: ANALYSIS OF THE PULSATILE CAPILLARY FLOW

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider