Key result
3D volumetric frequency-domain iOCT illustrates atherosclerotic plaque fibrous cap complexity in two cases.
Why the study?
Assessment of fibrous cap thickness by single cross-sectional iOCT images does not capture the complexity of atherosclerotic plaques, necessitating three-dimensional volumetric quantification.
Case Report (n=2)
Three-dimensional frequency-domain iOCT provides a more comprehensive assessment of thin-cap fibroatheroma complexity compared to single cross-sectional imaging.
Histopathological data correlated the presence of thin-cap fibroatheroma (TCFA) with adverse cardiovascular events. Intravascular optical coherence tomography (iOCT) is currently the only imaging modality with sufficiently high axial resolution (∼15 μm) that allows direct fibrous-cap (FC) assessment in vivo. iOCT quantification of TCFA has been validated, but the assessment of a single cross-sectional image does not depict the complexity of the atherosclerotic plaque. We present two cases that illustrate the importance of three-dimensional volumetric quantification of the FC capitalizing on the properties of frequency-domain iOCT.
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Bezerra et al. (2011) conducted a case report in Atherosclerotic plaque / Thin-cap fibroatheroma (n=2). Three-dimensional volumetric quantification using frequency-domain iOCT was evaluated. Three-dimensional volumetric quantification using frequency-domain intravascular optical coherence tomography illustrates the complexity of the atherosclerotic plaque fibrous cap in two cases.
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