Key result
Validated LC-MS/MS method successfully measures pharmacokinetics of four major Andrographis paniculata diterpenoids in human plasma.
Why the study?
Previous pharmacokinetic studies in humans reported only the parameters of andrographolide and its analytical method in human plasma, lacking simultaneous determination of all four major active diterpenoids.
Population
1 healthy Thai female volunteer
Comparison
Multiple oral doses of Andrographis paniculata product
Design
Pilot pharmacokinetic study using validated LC-MS/MS method
Authors
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Validated LC-MS/MS method supports expanded human PK studies of A. paniculata diterpenoids; clinical relevance remains undetermined.
A simple and sensitive LC-MS/MS method was successfully developed and validated for the simultaneous determination of four major active diterpenoids from Andrographis paniculata in human plasma.
Pholphana et al. (2015) studied Healthy (n=1). Andrographis paniculata product was evaluated on Pharmacokinetic parameters of four major active diterpenoids. A simple and sensitive LC-MS/MS method was successfully validated and used to determine the pharmacokinetic parameters of four major active diterpenoids from A. paniculata in a healthy volunteer.
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