Key result
New conceptual framework for cardiac ryanodine receptor organization promises to unify diverse observations in sparkology.
Why the study?
The exact nature of elemental calcium signals in terms of ryanodine receptor gating in situ in cardiac myocytes remains an enigma.
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Provides a conceptual framework for understanding ryanodine receptor array operation and calcium sparkology in cardiac myocytes.
Elemental calcium signals from RYR arrays operating in cardiac myocytes have been extensively characterized with ever-improving optical methods and other innovative techniques.However, the exact nature of elemental calcium signals in terms of RYR gating in situ remains an enigma.Here, we synthesize insights gleaned from recent developments in single-channel resolution of cardiac RYR organization and in visualization of calcium release events that are much smaller than calcium sparks.This synthesis leads to the proposal of a conceptual framework that promises to unify diverse observations in sparkology.
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Xie et al. (2010) reported a review. A conceptual framework synthesizing recent insights into single-channel cardiac ryanodine receptor organization and calcium release events promises to unify diverse observations in sparkology.
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