Key result
10% hydroxyethyl starch increases cardiac index and oxygen delivery vs lactated Ringer's in critically ill patients.
Why the study?
The cardiopulmonary effects of lactated Ringer's solution compared with 10% hydroxyethyl starch in critically ill patients were not well characterized.
Does 10% hydroxyethyl starch improve hemodynamics and oxygen transport compared to lactated Ringer's solution in critically ill patients?
RCT (n=15)
Does 10% hydroxyethyl starch improve hemodynamics and oxygen transport compared to lactated Ringer's solution in critically ill patients?
In critically ill patients, volume expansion with 10% hydroxyethyl starch improves hemodynamic and oxygen transport variables more effectively than lactated Ringer's solution.
The cardiopulmonary effects of lactated Ringer's solution (RL) were compared with those of 10% hydroxyethyl starch, hetastarch (HES), given in 44 therapeutic interventions in 15 critically ill patients by crossover design. Each agent was given to each patient at least once; seven patients received each agent twice. Infusions were continued until the wedge pressure (WP) had increased to 16 +/- 2 mm Hg in trauma patients and 18 +/- 2.mm Hg in cardiac patients. HES 10% produced significantly increased cardiac index, left and right ventricular stroke work index, CVP, WP, oxygen delivery, oxygen consumption, and reduced pulmonary vascular resistance index (PVRI). RL increased CVP, WP, and PVRI, but did not significantly improve other hemodynamic or oxygen transport variables.
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Hankeln et al. (1989) conducted an RCT in Critically ill patients (n=15). 10% hydroxyethyl starch (HES) vs. Lactated Ringer's solution (RL) was evaluated on Hemodynamic and oxygen transport variables. 10% hydroxyethyl starch significantly increased cardiac index, stroke work index, and oxygen delivery in critically ill patients, whereas lactated Ringer's solution did not improve these variables.
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