Key result
Regadenoson stress testing linked to reversible Takotsubo cardiomyopathy in a single case.
Why the study?
Takotsubo cardiomyopathy is usually related to massive physiological or emotional stressors, but its occurrence after regadenoson cardiac stress testing is not well documented.
Case Report (n=1)
This case report highlights that regadenoson cardiac stress testing may act as a physiological stressor capable of inducing Takotsubo cardiomyopathy.
Regadenoson stress testing may rarely trigger Takotsubo cardiomyopathy; this case leaves open questions on incidence and risk factors.
Takotsubo cardiomyopathy, also described as apical ballooning syndrome/stress-induced cardiomyopathy, imitates acute coronary syndrome and is usually related to a massive physiological or emotional stressor. We describe perhaps the first reported case to the best of our knowledge of a 55-year-old Caucasian woman who presented with congestive heart failure after having a regadenoson cardiac stress test a few hours prior to presentation to the hospital. Transthoracic echocardiogram revealed reduced heart function. She had normal coronaries on cardiac catheterisation, and left ventriculography confirmed apical ballooning syndrome. She underwent guideline-directed therapy, and heart function improved in the repeat echocardiogram along with clinical resolution of symptoms.
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Kalavakunta et al. (2017) conducted a case report in Takotsubo cardiomyopathy (n=1). Regadenoson cardiac stress test was evaluated on Development of Takotsubo cardiomyopathy. A regadenoson cardiac stress test induced Takotsubo cardiomyopathy in a 55-year-old woman, which resolved with guideline-directed therapy.
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