Key result
Hypertension in obesity is linked to a ~53-minute delay in the onset of insulin action.
Why the study?
Kinetic abnormalities in the onset of insulin action may contribute to insulin resistance in obesity-associated hypertension.
Does obesity-associated hypertension alter the kinetics of insulin action compared to normotensive obesity?
Comparison
Hypertensive obese subjects versus normotensive obese subjects
Design
Observational study using hyperinsulinemic euglycemic clamps
Follow-up
6 hours
Authors
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May indicate delayed insulin action onset in obese hypertension; hypothesis-generating, needs larger prospective confirmation.
Observational (n=18)
Does obesity-associated hypertension alter the kinetics of insulin action compared to normotensive obesity?
Absolute Event Rate: 91% vs 38%
p-value: p=< 0.05
Obesity-associated hypertension is linked to a slower rate of activation of insulin action rather than a reduced maximal steady-state insulin effect.
Biolo et al. (1998) conducted an observational in Obesity-associated hypertension (n=18). Hypertension vs. Normotension was evaluated on Time required to reach the half-maximal glucose infusion rate (p=< 0.05). In obese subjects, hypertension was associated with a slower rate of activation of insulin action, requiring 91 vs 38 minutes to reach half-maximal glucose infusion rate (P<0.05).
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