Key result
Pregnancy in liver transplant recipients is linked to severe complications in ~60% of cases.
Why the study?
Pregnancies after liver transplantation require evaluation for obstetric complications, maternal and neonatal outcomes, and post-pregnancy allograft function.
Observational (n=5)
No
Pregnancy in liver transplant recipients is associated with significant maternal and neonatal complications, including pre-eclampsia and long-term allograft dysfunction.
OBJECTIVE: To study pregnancies achieved after liver transplantation in terms of obstetric complications, maternal, neonatal outcomes and post-pregnancy allograft function. METHODS: A retrospective study of prospectively collected data was conducted, enrolling women with a history of liver transplantation performed in the Transplantation Unit of our hospital that delivered in our department. Obstetric characteristics and antenatal complications were reviewed. Apgar score, admission to Neonatal Intensive Care Unit (NICU) and need for emergency intubation were analyzed. Outcomes of regular follow-up concerning all complications of allograft function observed after pregnancy were also studied. RESULTS: There were five cases of allograft recipients delivering their pregnancies during the study period. Mean maternal age was 32.2 ± 5 years. Interval from transplantation to delivery ranged from 40 to 219 months. Mean gestational week at delivery was 34.4 ± 2.5 weeks. Antenatal complications observed were pre-eclampsia (3 of 5 cases) and vaginal bleeding (1 of 5 cases). All preterm neonates were admitted to NICU, but no emergency intubation was demanded. One patient died a month after delivery, while three others were complicated by implant dysfunction up to 5 years after the delivery. CONCLUSION: Pregnancy in a liver transplant recipient is associated with complications for mother and infant.
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Margioula‐Siarkou et al. (2015) conducted an observational in Pregnancy after liver transplantation (n=5). Pregnancy after liver transplantation was evaluated on Obstetric complications, maternal, neonatal outcomes and post-pregnancy allograft function. Pregnancy in liver transplant recipients was associated with complications, including pre-eclampsia in 3 of 5 cases, one maternal death, and implant dysfunction in 3 cases up to 5 years post-delivery.
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