Key result
Hemodialysis links to ~29% higher CIMT versus healthy controls despite similar LOX-1 levels.
Why the study?
Atherosclerotic cardiovascular disease risk is increased in hemodialysis patients, and the role of LOX-1 in this population is unclear.
Are LOX-1 levels and CIMT increased in hemodialysis patients compared to healthy controls?
Cross-Sectional (n=47)
No
Are LOX-1 levels and CIMT increased in hemodialysis patients compared to healthy controls?
Absolute Event Rate: 0.9% vs 0.7%
p-value: p=<0.001
Hemodialysis patients exhibit increased subclinical atherosclerosis as measured by CIMT, but this is not associated with elevated serum LOX-1 levels.
CIMT elevation signals subclinical atherosclerosis in hemodialysis; leaves open LOX-1's role as biomarker or mediator.
Objectives: Atherosclerotic cardiovascular disease risk is increased in hemodialysis patients. Oxidized low density lipoprotein has an important role in atherosclerotic process and it exerts this effect via lectin like oxidized low density lipoprotein-1 (LOX-1). Carotid artery intima-media thickness (CIMT) is accepted as a god indicator of subclinical atherosclerosis. In this study, we aimed to investigate LOX-1 and CIMT levels in hemodialysis patients. Methods: Twenty-eight patients treated with hemodialysis at least 6 months and 19 healthy subjects were enrolled in this study. Serum LOX-1 levels and simultaneously with CIMT were measured in hemodialysis patients and healthy control group. Results: CIMT value was found to be statistically significantly higher in the hemodialysis group compared to control group (0.9 mm in hemodialysis group vs. 0.7 mm in control group, p < 0.001). There was no statistically significant difference between groups in terms of LOX-1 levels. (0.172 ng/ml in hemodialysis group vs. 0.213 ng/ml in healthy control group, p > 0.05). Conclusions: Although cardiovascular risk markers like CIMT, CRP were higher in hemodialysis group as expected, increase in LOX-1 levels was not detected.
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Dağel et al. (2022) conducted a cross-sectional in End-stage renal disease on hemodialysis (n=47). Hemodialysis vs. Healthy controls was evaluated on Carotid artery intima-media thickness (CIMT) (p=<0.001). Hemodialysis patients had significantly higher carotid artery intima-media thickness compared to healthy controls (0.9 mm vs. 0.7 mm, p<0.001), but no significant difference in LOX-1 levels.
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