Key result
Apelin-13 reduces cerebral water content, blood-brain barrier destruction, and apoptosis after traumatic brain injury.
Why the study?
Secondary effects of apelin-13 on traumatic brain injury-induced neural cell death and blood-brain barrier integrity remain unclear.
Hypothesis-generating for apelin-13 in TBI; human trials needed before clinical consideration.
The adipocytokine, apelin-13, is an abundantly expressed peptide in the nervous system. Apelin-13 protects the brain against ischemia/reperfusion injury and attenuates traumatic brain injury by suppressing autophagy. However, secondary apelin-13 effects on traumatic brain injury-induced neural cell death and blood-brain barrier integrity are still not clear. Here, we found that apelin-13 significantly decreases cerebral water content, mitigates blood-brain barrier destruction, reduces aquaporin-4 expression, diminishes caspase-3 and Bax expression in the cerebral cortex and hippocampus, and reduces apoptosis. These results show that apelin-13 attenuates secondary injury after traumatic brain injury and exerts a neuroprotective effect.
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Wu et al. (2016) studied Traumatic brain injury. Apelin-13 was evaluated on Secondary injury (cerebral water content, blood-brain barrier destruction, apoptosis). Apelin-13 significantly decreases cerebral water content, mitigates blood-brain barrier destruction, and reduces apoptosis in the cerebral cortex and hippocampus after traumatic brain injury.
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