Key result
Antidepressant therapy improves quality of life but fails to improve cardiovascular prognosis.
Why the study?
Depression is linked to the development and worse outcomes of coronary artery disease, but the impact of depression treatment on cardiovascular prognosis remains unclear.
Does treatment of depression improve cardiovascular prognosis and quality of life in patients with coronary artery disease?
Population
Patients with coronary artery disease and depression or at risk for CAD
Comparison
Treatment of depression with selective serotonin reuptake inhibitors, tricyclic antidepressants, or Hypericum perforatum
Design
Review
Authors
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Depression may signal higher CAD risk; leaves open whether screening or treatment improves prognosis.
Does treatment of depression improve cardiovascular prognosis and quality of life in patients with coronary artery disease?
While treating depression in CAD patients improves quality of life, SSRIs are preferred over TCAs and St. John's wort due to better cardiovascular safety profiles, though no definitive improvement in cardiovascular prognosis has been proven.
Michael J. Zellweger (2003) conducted a review in Coronary artery disease and depression. Antidepressant therapy was evaluated. Depression is an independent risk factor for cardiac events, and while antidepressant therapy improves quality of life, it has not been shown to improve cardiovascular prognosis.
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