Key result
Saiga antelope horn reduces cardiovascular and renal lesions in hypertensive rats, an effect abolished by PAG.
Why the study?
Saiga antelope horn has been used to treat hypertension-related diseases, but its effectiveness and mechanism of action require clarification due to limited availability.
Does Saiga antelope horn reduce blood pressure and organ damage in spontaneously hypertensive rats?
Does Saiga antelope horn reduce blood pressure and organ damage in spontaneously hypertensive rats?
Saiga antelope horn exerts antihypertensive and organ-protective effects in spontaneously hypertensive rats, which appear to be mediated by hydrogen sulfide.
Does not support clinical use; leaves open H2S-mediated organ protection in hypertensive models.
ETHNOPHARMACOLOGICAL RELEVANCE: Saiga antelope horn (SAH), derived from the male Saiga tatarica Linnaeus, has been used in China for millennia to treat hyperpyretic convulsions and hypertension-related diseases. Clarifying its effectiveness and mechanism of action are essential because of its limited availability. This study will guide the investigation of alternative resources. AIM OF THE STUDY: S (hydrogen sulfide), other reactive sulfur species (RSS), and the renin-angiotensin-aldosterone system (RAAS). MATERIALS AND METHODS: S was tested with DL-propargylglycine (PAG), a cystathionine-γ-lyase (CSE) inhibitor. SAH organ protection was evaluated by histopathologic staining of artery, heart, and kidney tissue. RESULTS: S levels in arterial and intestinal tissue, and its antihypertensive activity was abolished by PAG treatment. SAH improved lesions and reduced collagen deposition in the kidneys, heart, and arteries in SHRs. CONCLUSION: S and other active sulfur and reactive oxygen species.
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Li et al. (2025) studied Hypertension. Saiga antelope horn (SAH) vs. DL-propargylglycine (PAG) / Control was evaluated on Antihypertensive activity and organ protection. Saiga antelope horn improved lesions and reduced collagen deposition in the kidneys, heart, and arteries in spontaneously hypertensive rats, an effect abolished by PAG treatment.
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