Key result
Higher serum VEGF inversely correlates with endothelium-dependent and independent dilatation in healthy postmenopausal women.
Why the study?
The correlation between serum vascular endothelial growth factor concentration and arterial reactivity in postmenopausal women was not established.
Does serum vascular endothelial growth factor (VEGF) concentration correlate with arterial reactivity in healthy postmenopausal women?
Observational (n=24)
Does serum vascular endothelial growth factor (VEGF) concentration correlate with arterial reactivity in healthy postmenopausal women?
Serum VEGF concentration is inversely correlated with brachial artery dilatation, suggesting it may serve as a non-invasive biomarker for arterial reactivity in healthy postmenopausal women.
Answers are grounded in this paper and cite their sources.
VEGF-arterial reactivity association in low-risk postmenopausal women is hypothesis-generating; leaves open any role in cardiovascular risk assessment.
OBJECTIVE: To determine whether serum vascular endothelial growth factor (VEGF) concentration is correlated with arterial reactivity in postmenopausal women. METHODS: An observational study was conducted on 24 postmenopausal women who did not receive any hormone therapy in the 6 months preceding the study and had no pre-existing cardiovascular diseases or cardiovascular risk factors. Serum samples were obtained from all participants and analyzed for VEGF concentrations. Arterial reactivity was assessed by the measurement of endothelium-dependent dilatation and endothelium-independent dilatation of the brachial artery, using color duplex Doppler ultrasound. RESULTS: The study population was aged 50.8 years on average, with about 2 years of menopause. Serum VEGF concentration in postmenopausal women was significantly correlated with both endothelium-dependent dilatation (r = -0.66, p < 0.01) and endothelium-independent dilatation (r = -0.65, p < 0.01) of the brachial artery. CONCLUSIONS: Serum VEGF level may be a potential indicator of arterial reactivity in postmenopausal women.
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Lam et al. (2006) conducted an observational in Postmenopausal women (n=24). Serum vascular endothelial growth factor (VEGF) concentration was evaluated on Endothelium-dependent dilatation of the brachial artery (r = -0.66, p=<0.01). Serum VEGF concentration in healthy postmenopausal women was significantly inversely correlated with both endothelium-dependent (r = -0.66, p < 0.01) and endothelium-independent dilatation.
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