Constrictive pericarditis due to Cryptococcus neoformans in an elderly immunosuppressed patient

Introduction: involvement is exceptional outside the context of HIV but may occur in immunosuppressed patients. Case description: infection. She received antifungal therapy (liposomal amphotericin B plus flucytosine, followed by fluconazole) with a favourable 12-month outcome. Discussion: This case illustrates the importance of considering fungal aetiologies in immunosuppressed patients with pericardial disease. Pericardiectomy was both diagnostic and therapeutic. Antifungal therapy according to international guidelines ensured clinical success. Conclusion: Cryptococcal pericarditis, though rare, should be considered in immunosuppressed patients with pericardial effusion or thickening. A combined approach with surgery and antifungals is essential. LEARNING POINTS: Cryptococcal pericarditis is rare but should be suspected in immunosuppressed patients with pericardial effusion or thickening.Pericardiectomy is crucial as both a diagnostic and therapeutic intervention in constrictive pericarditis.Sequential antifungal treatment, in accordance with international guidelines, leads to favourable outcomes.