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Hepatic glucose-6-phosphatase activity appears in developing chicken embryo almost simultaneously with appearance of first hepatic cells. Glucose-6-phosphatase and β-glucuronidase activity of embryo increase in direct proportion to liver weight. Properties of embryonic liver glucose-6-phosphatase are similar to those found in adult liver of other species. Studies with liver slices indicate that the embryo liver is capable of glycogenolysis and glucose formation.
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Kilsheimer et al. (1960) studied this question.
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