Key result
Estrogen up-regulates uterine basigin expression linked to implantation in mice.
Why the study?
Basigin is essential for fertilization and implantation, but its expression and hormonal regulation in mouse uterus during the peri-implantation period were not fully characterized.
Population
Mouse uterus during the peri-implantation period including ovariectomized and delayed-implantation models
Comparison
Estrogen injection and artificial decidualization vs baseline conditions
Design
Preclinical study
Authors
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Hypothesis-generating for basigin in mouse implantation; human relevance and therapeutic potential remain untested.
Basigin expression in the mouse uterus is dynamically regulated during the peri-implantation period and is up-regulated by estrogen.
Xiao et al. (2002) studied Pregnancy and peri-implantation. Estrogen was evaluated on Basigin expression and hormonal regulation. Basigin expression in the mouse uterus is closely related to implantation and is significantly up-regulated by estrogen.
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