Key result
Chagas disease linked to ~9% greater stroke risk compared to other cardiopathies.
Why the study?
Chagas disease is frequently associated with cardioembolic stroke in South America, but predictors of stroke in regions where CD is endemic need identification.
Observational (n=305)
Odds Ratio: 1.09 (95% CI 1.02–1.17)
Absolute Event Rate: 15% vs 6.3%
p-value: p=0.015
Chagas disease was associated with higher stroke rates in cardiopathy; leaves open whether targeted screening or anticoagulation improves outcomes in endemic regions.
BACKGROUND AND PURPOSE: Chagas disease (CD) is frequently associated with cardioembolic stroke in South America. Our objective was to identify the predictors of stroke in a region where CD is endemic. METHODS: We screened 305 consecutive cardiopathy patients. Significant predictors of stroke in univariable analyses were included in a multivariable model. RESULTS: Stroke was more frequent in CD (15.0%) compared with other cardiopathies (6.3%; P=0.015). Other predictors of stroke in univariable analyses were previous diabetes or cardioversion and use of amiodarone, antiplatelet agents, and warfarin. In multivariable analysis, remaining predictors of stroke were CD (odds ratio [OR], 1.09; 95% CI, 1.02 to 1.17), cardioversion (OR, 1.07; 95% CI, 1.02 to 1.13), and diabetes (OR, 1.12; 95% CI, 1.01 to 1.24). CONCLUSIONS: In conclusion, CD is a risk factor for stroke, independent of systolic dysfunction or presence of cardiac arrhythmias.
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Oliveira‐Filho et al. (2005) conducted an observational in Cardiopathy (n=305). Chagas disease vs. Other cardiopathies was evaluated on Stroke (OR 1.09, 95% CI 1.02-1.17, p=0.015). Chagas disease was an independent predictor of stroke among patients with cardiopathy, occurring more frequently than in other cardiopathies (15.0% vs 6.3%; OR 1.09, 95% CI 1.02-1.17).
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