Key result
99mTc-HYNIC-PSMA-11 SPECT/CT surpasses conventional imaging for detecting peritoneal carcinomatosis in metastatic prostate cancer.
Why the study?
Conventional anatomical imaging techniques such as CT scans have limited soft tissue resolution for assessing peritoneal involvement in metastatic prostate cancer.
Case Report (n=1)
Functional imaging with 99mTc-HYNIC-PSMA-11 scintigraphy and SPECT/CT can surpass anatomical imaging in assessing peritoneal involvement in prostate cancer.
May aid peritoneal metastasis detection in prostate cancer; leaves open need for prospective validation beyond this case.
We present a 73-year-old man with de novo metastatic prostate cancer who had received chemotherapy and androgen deprivation therapy (ADT). An increase in his serum prostate-specific antigen (PSA) level during ADT prompted a referral for restaging. A 99m Tc-HYNIC-PSMA-11 scintigraphy was conducted, which revealed uptake in the peritoneal cavity that was initially interpreted as normal intestinal excretion on the whole body scan but was later clarified through SPECT/CT imaging. This case underscores the potential of functional imaging, even conventional methods, to surpass anatomical imaging techniques such as CT scans, which have limited soft tissue resolution, in assessing peritoneal involvement.
No takes yet. Share an insight, caveat, or question.
Raeisi et al. (2025) conducted a case report in Metastatic prostate cancer (n=1). 99mTc-HYNIC-PSMA-11 scintigraphy with SPECT/CT vs. Anatomical imaging (CT scans) was evaluated on Detection of peritoneal carcinomatosis. 99mTc-HYNIC-PSMA-11 scintigraphy with SPECT/CT successfully detected peritoneal carcinomatosis in a patient with metastatic prostate cancer, surpassing conventional anatomical imaging.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: