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By means of the leucocyte migration technique it is demonstrated that a hypersensitivity of the delayed type seems to be involved in the hypertensive disease in patients suffering from primary essential hypertension. The migration index is lower than 1.0 in the hypertensive patients, indicating an inhibition of the leucocyte migration, while the index in normotensive control persons shows practically no inhibition. The hypersensitivity is directed towards antigenic substances in the aortic wall of rabbits.
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Olsen et al. (1973) studied this question.
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