Without fragmentation: The mass spectrometric analysis of biological macromolecules can be achieved without fragmentation of the parent molecule by using the technique of soft laser (matrix-assisted laser desorption/ionization (MALDI; see scheme, UFMP=ultrafine metal-powder matrix). The development of this technique was greatly influenced by the work of Koichi Tanaka for which he was awarded the Nobel Prize for Chemistry in 2002.
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Koichi Tanaka (2003) studied this question.
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