Key result
Elevated serum ischemia-modified albumin identifies preeclampsia with ~80% sensitivity and correlates with disease severity.
Why the study?
Serum ischaemia-modified albumin levels in normal pregnant and preeclamptic women, including mild and severe cases, were not well characterized.
Do serum ischemia-modified albumin (IMA) levels correlate with the presence and severity of preeclampsia in pregnant women?
Case-Control (n=54)
Do serum ischemia-modified albumin (IMA) levels correlate with the presence and severity of preeclampsia in pregnant women?
Effect estimate: Sensitivity 80%, Specificity 77.8%
Serum ischemia-modified albumin levels are elevated in preeclampsia and correlate with disease severity, suggesting potential utility as a biomarker.
May aid preeclampsia detection; leaves open prospective validation before clinical adoption.
OBJECTIVE: We examined serum ischaemia-modified albumin (IMA) levels in normal pregnant and preeclamptic women. The primary aim of our study was to assess IMA in women with mild and severe preeclampsia. METHODS: Serum ischaemia-modified albumin levels were measured in 18 normotensive and 36 preeclamptic pregnant women by enzyme linked immuno-sorbent assay. Patients were subdivided as having either mild (n=18) or severe preeclampsia (n=18). Receiver operating characteristic curve was constructed, and sensitivity and specificity were calculated based on the best cut-off. RESULTS: IMA levels were significantly higher in the mild and severe preeclamptic groups than in the control group. IMA with a cut-off point of 0.31 identified women with preeclampsia with sensitivity 80% and specificity 77.8%. CONCLUSION: Our study demonstrates that serum levels of IMA correlate with severity of preeclampsia.
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Üstün et al. (2010) conducted a case-control in Preeclampsia (n=54). Serum ischaemia-modified albumin (IMA) vs. Normotensive pregnant women was evaluated on Identification of preeclampsia using IMA cut-off of 0.31 (Sensitivity 80%, Specificity 77.8%). Serum ischemia-modified albumin levels >0.31 identified women with preeclampsia with 80% sensitivity and 77.8% specificity, and correlated with disease severity.
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