The mechanism behind the association of elevated plasma lipoprotein(a) [Lp(a)] levels with atherosclerotic disease is unknown. In the present study, Lp(a) induced generation of oxygen free radicals by monocytes from selected healthy individuals in vitro. This observation may provide a link between Lp(a) and generation of oxidized LDL, which can promote multiple atherogenic cellular responses.
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Hansen et al. (1994) studied this question.
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