Key result
Pre-diabetic HbA1c shows no association with major coronary events in non-diabetic stable angina.
Why the study?
Associations of glycated hemoglobin A1c levels to incident coronary and cardiovascular events among non-diabetic patients with coronary artery disease are unclear.
Do HbA1c levels predict major coronary events in non-diabetic patients with suspected stable angina pectoris?
Cohort (n=2,519)
Do HbA1c levels predict major coronary events in non-diabetic patients with suspected stable angina pectoris?
Hazard Ratio: 1.13 (95% CI 0.79–1.62)
p-value: p=0.49
HbA1c levels within the pre-diabetic range do not independently predict major coronary events or mortality in non-diabetic patients with suspected stable angina pectoris.
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No association with events does not support HbA1c-based risk stratification in suspected stable angina; leaves open prospective trials of prediabetes management.
Rebnord et al. (2015) conducted a cohort in Suspected stable angina pectoris without diabetes mellitus (n=2,519). HbA1c levels in the pre-diabetic range (5.7-6.4%) vs. HbA1c 5.0-5.6% (reference) was evaluated on Major coronary events (including non-fatal and fatal acute myocardial infarctions, and sudden cardiac death) (HR 1.13, 95% CI 0.79-1.62, p=0.49). In non-diabetic patients with suspected stable angina pectoris, HbA1c levels in the pre-diabetic range were not associated with major coronary events (HR 1.13; 95% CI 0.79-1.62; P=0.49).
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