Key result
Mouse Cappb1 gene maps to Chromosome 4 between Cdc42 and D4Mit312.
Why the study?
The chromosomal location of the mouse actin capping protein beta subunit gene was not previously identified.
The mouse actin capping protein beta subunit gene (Cappb1) was mapped to Chromosome 4, in the vicinity of mutations for snubnose, curly tail, and cribriform degeneration.
BACKGROUND: Capping protein (CP), a heterodimer of alpha and beta subunits, is found in all eukaryotes. CP binds to the barbed ends of actin filaments in vitro and controls actin assembly and cell motility in vivo. Vertebrates have three isoforms of CPbeta produced by alternatively splicing from one gene; lower organisms have one gene and one isoform. RESULTS: We isolated genomic clones corresponding to the beta subunit of mouse CP and identified its chromosomal location by interspecies backcross mapping. CONCLUSIONS: The CPbeta gene (Cappb1) mapped to Chromosome 4 between Cdc42 and D4Mit312. Three mouse mutations, snubnose, curly tail, and cribriform degeneration, map in the vicinity of the beta gene.
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Hart et al. (2000) studied this question. The mouse capping protein beta subunit gene (Cappb1) was mapped to Chromosome 4 between Cdc42 and D4Mit312.
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