Key result
Capping protein lacking both COOH-terminal regions did not bind actin, and in vivo rescue of null mutant phenotypes correlated well with capping activity.
The COOH-terminal regions of capping protein are essential for actin binding in yeast, and capping is a physiological function for CP in vivo.
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Supports CP domain function in yeast actin regulation; hypothesis-generating for cytoskeletal mechanisms in mammalian cardiomyocytes.
Kim et al. (2004) studied this question. Recombinant mutant yeast capping protein (CP) was evaluated on Actin binding and rescue of null mutant phenotypes. Capping protein lacking both COOH-terminal regions did not bind actin, and in vivo rescue of null mutant phenotypes correlated well with capping activity.
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