Key result
Measuring increases in blood protein levels or activities in response to vascular stress may be a feasible way to distinguish between normo- and hypercoagulable individuals.
Suggests that measuring coagulation responses to vascular stress may be more reliable than baseline assays for identifying hypercoagulable individuals.
Although it may be impossible to distinguish reliably between normo- and hypercoagulable individuals on the basis of results from single assays of so-called baseline or resting levels of proteins or activities in blood, it might be feasible to do so by measuring the increases in the levels or activities in response to some kind of vascular stress, such as stasis or adequately reproducible vascular injury
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J H Joist (1990) conducted a review in Hypercoagulability. Measuring increases in protein levels or activities in response to vascular stress vs. Baseline or resting levels was evaluated. Measuring increases in blood protein levels or activities in response to vascular stress may be a feasible way to distinguish between normo- and hypercoagulable individuals.
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